One hundred countries representing 4.5 billion people have signed the global treaty aimed at curbing tobacco use, which now claims nearly 5 million lives every year and causes an estimated an num net loss of $200 billion in treatment and lost productivity, the United Nations health agency reporteD、 The treaty requires signed countries to restrict tobacco advertising, sponsorship and promotion, set new labeling and clean indoor air controls and strengthen legislation to clamp down on tobacco smuggling.At the time of its unanimous adoption last May by WHO’s 192 members, the agency warned that the annual death toll of 4.9 million, if left unchecked, could double by 2020. The tobacco epidemic is still expanding, especially in developing countries where currently seven out of every 10 tobacco-related deaths occur, according to WHO.At current rates, the total number of tobacco users is expected to rise to 1.7 billion by 2025 from 1.3 billion now. TheEuropeanCommunityEC、has also signed the treaty as a regional economic integration organization, while its member states sign and ratify the treaty individually.