【单选题】

Scientists at Washington University School of Medicine in the US found higher levels of protein S1PR2 (磷酸鞘氨醇受体蛋白) in tests on the brains of female mice and dead women with MS than in male equivalents. Four times more women than men are currently diagnosed with Multiple Sclerosis (多发性硬化症).

Experts said the finding was "really interesting". MS affects the nerves in the brain and spinalCord, which causes problems with muscle movement, balance and vision. It is a major cause of disability, and affects about 100,000 people in the UK.Abnormal immune cells attack nerve cells in the central nervous system in MS patients. There is currently no cure, although there are treatments that can help in the early stages of the disease.
Researchers in Missouri looked at relapsing remitting (复发缓解型) MS, where people have distinct attacks of symptoms that then fade away either partially or completely.About 85% of all people with MS have this type. Scientists studied the blood vessels and brains of healthy mice, mice with MS, and mice without the gene for S1PR2, a blood vessel receptor protein, to see how it affected MS severity. They also looked at the brain tissue samples of 20 people after they had dieD、They found high levels of SIPR2 in the areas of the brain typically damaged by MS in both mice and people. The activity of the gene coding for S1PR2 was positively correlated with the severity of the disease in mice, the study saiD、
Scientists said S1PR2 could work by helping to make the blood-brain barrier, in charge of stopping potentially harmful substances from entering the brain and spinal fluid, more permeable.A、more permeable barrier could let attacking cells, which cause MS, into the central nervous system, the study saiD、This link [between MS and S1PR2] is completely new—it has never been found before.
DrEmma Gray, of the MS Society, said: "We don’t yet fully understand why MS affects more women than men, and it’s an area that’s intrigued scientists, and people with MS, for many years. She said understanding the causes of MS was a "priority" for the MS Society in the UK, and could be "crucial" in finding new treatments.
What problem does MS mainly cause
A、Ill-natured muscle movement. B、Bad balance.
C、Disability. D、Bad eyesight.